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Insect physiology, signalling and communication - UMR_A 1272

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Insect physiology, signalling and communication - UMR_A 1272

The Research Unit 1272 "Insect Physiology: Signalling and Communication" was created on January 2005. It associates staff belonging to two different research and teaching institutes:



The Research Unit is directed by Martine Maïbèche (UPMC), with Emmanuelle Jacquin-Joly (INRA), Philippe Lucas (INRA) and Didier Rochat (INRA) as co-directors. The staff includes 35 persons with a permanent position (15 scientists and 20 engineers, technicians or administratives) and 15 students (PhD and master) or postdocs. The Research Unit is organized in two teams that study different aspects of insect signaling and communication.

In this page

Research activities


In a context of sensory neurobiology, our research aims at elucidating the mechanisms of signaling and communication involved in the interaction between insects and their environment and in the adaptation of their physiology and behaviour. Our experimental approaches cover the molecular, cellular and whole insect levels. Our insect models are mainly focused on pest species of economic importance in order to contribute to the development of integrated pest management.

The Research Unit is located on 2 sites:

INRA, VersaillesNouvelle fenêtre
Route de Saint Cyr
78026 Versailles Cedex, FRANCE
Tél : +33 1 30 83 31 01 - Fax : + 33 1 30 83 31 19

UPMC, ParisNouvelle fenêtre
7 quai Saint Bernard
Bât A, boîte courrier 1211
75252 Paris Cedex 05, FRANCE
Tél : + 33 1 44 27 65 87 - Fax : +33 1 44 27 65 09


Teams and research themes

Signals, reception, adaptation

Research interests:

In our team we investigate the specificity and the dynamic of the peripheral olfactory system. We analyze at the cellular and molecular levels the contribution of antennal events in the olfactory response and its modulation using an integrated approach including molecular, biochemical, physiological and neurobiological tools. We use the pheromone communication in moths as a biological model because of its high sensitivity, specificity and the stereotyped behaviours induced. Two species are used, an academic model, the silkworm Bombyx mori for which the genome is fully sequenced and genetic tools are available, as well as an European crop pest, the cotton leafworm Spodoptera littoralis for practical applications.


Objectives :
  • to identify and functionally characterize the various genes involved,
  • to study the regulation of their expression/function by the circadian clock and the physiological status of the animal,
  • to construct a model of these interactions in order to obtain a general understanding of olfactory signal reception at the peripheral level.

These studies aim at understanding how the pheromone signal is processed at the peripheral level, and the plasticity of the system. Our results will participate to a better understanding of the "olfactory logic” by which an odour is detected, discriminated and, in collaboration with the team “Coding and plasticity”, finally integrated at the central level, inducing a response from the animal.


  • Moutaz Ali Agha, PhD student
  • Catherine Blais, assistant professor
  • Françoise BozzolanNouvelle fenêtre, engineer
  • Thomas Chertemps, assistant professor
  • Nicolas Durand, ATER
  • Marie-Christine François, technician
  • Brigitte Frérot, engineer
  • Aurore Gallot, post-doc
  • Nicolas Glaser, PhD student
  • Alexandra Guigue, PhD student
  • Emmanuelle Jacquin-JolyNouvelle fenêtre, senior scientist
  • Ené Leppik, PhD student
  • Martine Maïbèche-CoisnéNouvelle fenêtre, professor
  • Annick Maria, technician
  • Frédéric Marion-PollNouvelle fenêtre, professor
  • Olivier Mirabeau, post-doc
  • Christelle Monsempes, engineer
  • Nicolas Montagné, assistant professor
  • Marie-Anne Pottier, PhD student
  • David SiaussatNouvelle fenêtre, assistant professor
  • Marthe Solvar, technician
  • Isabelle Touton, technician
  • Philippe Touton, technician


Coding, behaviour, modulation

Research interests:

Our experimental and modelling studies aim at understanding the mechanisms involved in the recognition of the olfactory signal and its translation in a behavioural response adapted to the environment and the physiological state of the insect. These studies concern the processes of sensory coding, from the chemo-electrical transduction in the peripheral olfactory system (in the olfactory receptor neurones) to its integration in the central nervous system (by the neuronal network of the antennal lobe) and the resulting oriented locomotive response. We also analyse how the insect responds to a specific signal in a complex sensory environment (interactions of pheromones and plant volatile compounds) and the mechanisms of the modulation of the olfactory response (by steroid hormones).

We use different approaches including anatomy (quantitative neuroanatomy, intracellular stainings), molecular biology (cloning, in situ hybridization, RNA interference, heterologous expression), electrophysiology (intra- and extracellular, patch clamp in vivo and in vitro), imaging (calcium imaging), ethology (olfactometry, trajectometry), biochemistry (immuno-dosage of steroids), physico-chemistry (gas chromatography coupled to behaviour), and modelling (statistical analyses, computer simulation, robotics) to study the functioning of neurons and neuron networks on one side and modifications of this functioning on the other side.

Our studies are realized on three species of phytophagous insects. We use the model of pheromone communication in moths, on the noctuids Spodoptera littoralis and Agrotis ipsilon, because of its sensitivity, specificity and stereotyped behavioural responses involved. Responses to the pheromone in interaction with plant volatiles are also studied in the context of an applied project, on the invasive weevil Rhynchophorus ferrugineus.



•   To study and model how the quality, intensity and time pattern of olfactory signals are encoded in the peripheral and central nervous system.

•   To decipher and model the signalling pathway of the olfactory transduction.

•   To study the mechanisms underlying plasticity linked to the physiological state.

•   To analyse interactions between odorants compounds, in particular between pheromone and plant voltile compounds.

•   To better estimate the role of complex chemical signals of the environment in the modulation of long distance attraction for their agronomical use (Rhynchophorus).


Members :

•          Antoine Abrieux, PhD student

•          Philippe Couzi, technician

•          Matthieu Dacher, assistant professor

•          Céline Defaix, post-doc

•          Stéphane Debernard, assistant professor

•          Nina Deisig, research scientist

•          Elodie Demondion, technician

•          Line Duportets, assistant professor

•          Christophe Hanot, technician

•          Lisa Lalouette, post-doc

•          Denis Limousin, post-doc

•          Philippe Lucas, senior scientist

•          Christelle Monsempes, engineer

•          Michel Renou, senior scientist

•          Didier Rochat, research scientist

•          Jean-Pierre Rospars, senior scientist

•          Angela Rouyar, PhD student

•          Marthe Solvar, technician

Doctoral schools
Scientific parternships


Fédération de Recherche : FR 9020, UPMC-INRA-CNRS-Cemagref-IRD-MNHN,

Fédération Ile de France de Recherche sur l’Environnement (FIRE)


  • SLU (Suède)
  • CSIRO (Australie)
  • Fondation Edmund Mach (Italie)
  • Université de Cambridge (Grande Bretagne)
  • Université de Pérouse (Italie)
  • Université américaine de Beyrouth (Liban)
  • Université de Tizi Ouzou (Algérie)
  • Université d’Agriculture de Damas (Syrie)
  • Université d’Alexandrie (Egypte)
  • Université California Davis, USA
  • University of Sussex, Brighton, Grande Bretagne (T. NowotnyNouvelle fenêtre)
  • Institut de Physiologie, Académie des Sciences, Prague, République Tchèque (P. LanskyNouvelle fenêtre)
  • University of Vienna, Autriche (H. TichyNouvelle fenêtre)
  • National Institute of Biology, Ljubljana, Slovénie
  • Institut Polytechnique de Valence, Espagne
  • Université Jaume I, Valence, Espagne
  • Université de Palerme, Italie
  • Consejo Superior de Investigaciones CientíficasNouvelle fenêtre (CSIC), Barcelone, Espagne
Main equipements


  • Tropical and temperate insect rearing rooms
  • Green houses
  • Cell culture
  • Protein electrophoresis
  • Immunodetection (Western-blot)
  • PCR, RT-PCR, quantitative PCR
  • Molecular cloning
  • Bacteriology
  • Hybridizations: in situ, northern-blot
  • Fluorescence and microscopy
  • RNA interference protocols
  • Heterologous expression
  • Patch clamp (in vivo / in vitro)
  • Intracellular recording
  • Monosensillar olfactory recording
  • Monosensillar taste recording
  • Calcium imaging (in vivo / in vitro)
  • Actograph
  • Olfactometry
  • Wind tunnels
  • Locomotion compensator (ServoSphere )
  • Gas chromatographs
  • Mass spectrometer
Main publications



  • A’Hara S.W., Amouroux P., Argo E.E., Avand-Faghih A., Barat A., Barbieri L., Bert T.M., Blatrix R., Blin A., Bouktila D., Broome A., Burban C., Capdevielle-Dulac C., Casse N., Chandra S., Cho K.J., Cottrell J.E., Crawford C.R., Davis M.C., Delatte H., Desneux N., Djieto-Lordon C., Dubois M.P., El-Mergawy R.A.A.M., Gallardo-Escarate C., Garcia M., Gardiner M.M., Guillemaud T., Haye P.A., Hellemans B., Hinrichsen P., Jeon J.H., Kerdelhue C., Kharrat I., Kim K.H., Kim Y.Y., Kwan Y.-S., Labbe E.M., Lahood E., Lee K.M., Lee W.-O., Lee Y.-H., Legoff I., Li H., Lin C.-P., Liu S.S., Liu Y.G., Long D., Maes G.E., Magnoux E., Mahanta P.C., Makni H., Makni M., Malausa T., Matura R., Mckey D., Mcmillen-Jackson A.L., Mendez M.A., Mezghani-Khemakhem M., Michel A.P., Paul M., Muriel-Cunha J., Nibouche S., Normand F., Palkovacs E.P., Pande V., Parmentier K., Peccoud J., Piatscheck F., Puchulutegui C., Ramos R., Ravest G., Richner H., Robbens J., Rochat D., Rousselet J., Saladin V., Sauve M., Schlei O., Schultz T.F., Scobie A.R., Segovia N.I., Seyoum S., Silvain J.-F., Tabone E., Van Houdt J.K.J., Vandamme S.G., Volckaert F.A.M., Wenburg J., Willis T.V., Won Y.-J., Ye N.H., Zhang W., Zhang Y.X. Permanent Genetic Resources added to Molecular Ecology Resources Database 1 August 2011-30 September 2011. Molec. Ecol. Res. 12:185–189
  • Bengtsson J.M., Trona F., Montagne N., Anfora1 G., Ignell R., Witzgall P., Jacquin-Joly E. Putative chemosensory receptors of the codling moth, Cydia pomonella, identified by antennal transcriptome analysis. PLoS One 7(2):e31620.
  • Bigot L., Abdul Shaik H., Bozzolan F., Party V., Lucas P., Debernard S., Siaussat D. Peripheral regulation by ecdysteroids of olfactory responsiveness in male Egyptian cotton leafworms, Spodoptera littoralis. Insect Biochem. Molec. Biol. 42:22-31.
  • Chaffiol A., Kropf J., Barrozo R.B., Gadenne C., Rospars J.P., Anton S. Plant odour stimuli reshape pheromonal representation in neurons of the antennal lobe macroglomerular complex of a male moth. J. Exp. Biol. 215:1670-1680.
  • Chertemps T., François A., Durand N., Rosell G., Dekker T., Lucas P., Maïbèche M. A carboxylesterase, Esterase-6, modulates sensory physiological and behavioural response dynamics to pheromone in Drosophila. BMC Biology 10:56.
  • Chertemps T., Montagné N., Bozzolan N., Maria M., Durand N., Maïbèche-Coisne M. Characterization of maspardin, responsible for human Mast syndrome, in an insect species and analysis of its evolution in metazoans. Naturwissenchaften 99(7):537-543.
  • Deisig N., Kropf J., Vitecek S., Pevergne D., Rouyar A., Sandoz J.-C., Lucas P., Gadenne C., Anton S., Barrozo R. Differential interactions of sex pheromone and plant odour in the olfactory pathway of a male moth. PLoS One 7(3):e33159.
  • Delle-Vedove R., Beaudoin-Ollivier L., Hossaert-Mckey M., Frérot B. Reproductive biology of the palm borer, Paysandisia archon (Lepidoptera: Castniidae). Eur. J. Entomol. 109:289-292.
  • Duportets L., Bozzolan F., Abrieux A., Maria A., Gadenne C., Debernard S. The transcription factor Krüppel homolog 1 is linked to the juvenile hormone-dependent maturation of sexual behavior in the male moth, Agrotis ipsilon. Gen. Comp. Endocrinol. 176:158-166.
  • Grémiaux A., Nowotny T., Martinez D., Lucas P., Rospars J.-P. Modelling the signal delivered by a population of first-order neurons in a moth olfactory system. Brain Res. 1434:123-135.
  • Guerrieri F., Gemeno C., Monsempes C., Anton S., Jacquin-Joly E., Lucas P., Devaud J.-M. Experience-dependent modulation of antennal sensitivity and input to antennal lobes in male moths (Spodoptera littoralis) pre-exposed to sex pheromone. J. Exp. Biol. 215:2334-2341.
  • Jacquin-Joly E., Legeai F., Montagné N., Monsempes C., François M.-C., Poulain J., Gavory F., Walker W.B., Hansson B.S., Larsson M.C. Candidate chemosensory genes in female antennae of the noctuid moth Spodoptera littoralis. Int. J. Biol. Sci. 8(7):1036-1050.
  • Leppik E., Frérot B. Volatile organic compounds and host-plant specialization in European corn borer E and Z pheromone races Chemoecology 22(2):119-129.
  • Minoli S., Kauer I., Colson V., Party V., Renou M., Anderson P., Gadenne C., Marion-Poll F., Anton S. Brief exposure to sensory cues elicits stimulus-nonspecific general sensitization in an insect. PloS One 7(3): e34141.
  • Montagné N., Chertemps T., Brigaud I., François A., François M.-C., Lucas P., Larsson M. C., Jacquin-Joly E. Functional characterization of a sex pheromone receptor in the pest moth Spodoptera littoralis by heterologous expression in Drosophila. Eur. J. Neurosci. (accepted).
  • Néant I., Deisig N., Scerbo P., Leclerc C., Moreau M. The RNA-binding protein Xp54nrb isolated from a Ca2+-dependent screen is expressed in neural structures during Xenopus laevis development. Int. J. Dev. Biol. 55: 923-931.
  • Piesik D., Rochat D., Delaney K.J. & Marion-Poll F. Orientation of European corn borer first instar larvae to synthetic green leaf volatiles. J. Appl. Entomol. (accepted).
  • Poivet E., Rharrabe K., Monsempes C., Glaser N., Rochat D., Renou M., Marion-Poll F., and Jacquin-Joly E. The use of sex pheromone as an evolutionary solution to food source selection in caterpillars. Nat Comm. (accepted).
  • Soares S.F., Louly C.C.B., Neves C.A., Marion-Poll F., and Borges L.M.F. Detection of phytoecdysteroids by gustatory sensilla on chelicerae of the brown dog tick Rhipicephalus sanguineus. Physiol. Entomol. 37(3):241-249.
  • The Heliconius Genome Consortium Butterfly genome reveals promiscuous exchange of mimicry adaptations among species Nature doi:10.1038/nature11041
  • Trabalon M., Blais C. Juvenile development, ecdysteroids and hemolymph level of metabolites in the spider Brachypelma albopilosum (Theraphosidae). J. Exp. Zool. Part A 317(4):236-247.



  • Anton S., Gadenne C., Marion-Poll F. Frontiers in invertebrate physiology – grand challenge. Front. Physiol. 2:38. doi: 10.3389/fphys.2011.00038.
  • Avargues-Weber A., Deisig N., Giurfa M. Visual cognition in social insects. Annu. Rev. Entomol. 56:423-443.
  • Anton S., Evengaard K., Barrozo R.B., Anderson P., Skals N. Brief predator sound exposure elicits behavioral and neuronal long-term sensitization in the olfactory system of an insect. Proc. Natl. Acad. Sci. USA 108(8):3401-3405.
  • Barrozo R.B., Jarriault D., Deisig N., Gemeno C., Monsempes C., Lucas P., Gadenne C., Anton S. Mating-induced differential coding of plant odour and sex pheromone in a male moth. Eur. J Neurosci. 33:1841-1850.
  • Belmabrouk H., Nowotny T., Rospars J.-P., Martinez D. Interaction of cellular and network mechanisms for efficient pheromone coding in moths. Proc. Natl. Acad. Sci. USA 108:19790-19795.
  • Durand N., Carot-Sans G., Bozzolan F., Rosell G., Siaussat D., Debernard S., Chertemps T., Maïbèche-Coisné M. Degradation of pheromone and plant volatile components by a same odorant-degrading enzyme in the cotton leafworm, Spodoptera littoralis. PLoS One 6(12):e29147. Epub 2011 Dec 27.
  • Grbic M., Van Leeuwen T., Clark R. M., Rombauts S., Rouze P., Grbic V., Osborne E. J., Dermauw W., Ngoc P. C., Ortego F., Hernandez-Crespo P., Diaz I., Martinez M., Navajas M., Sucena E., Magalhaes S., Nagy L., Pace R. M., Djuranovic S., Smagghe G., Iga M., Christiaens O., Veenstra J. A., Ewer J., Villalobos R. M., Hutter J. L., Hudson S. D., Velez M., Yi S. V., Zeng J., Pires-daSilva A., Roch F., Cazaux M., Navarro M., Zhurov V., Acevedo G., Bjelica A., Fawcett J. A., Bonnet E., Martens C., Baele G., Wissler L., Sanchez-Rodriguez A., Tirry L., Blais C., Demeestere K., Henz S. R., Gregory T. R., Mathieu J., Verdon L., Farinelli L., Schmutz J., Lindquist E., Feyereisen R. et Van de Peer Y. The genome of Tetranychus urticae reveals herbivorous pest adaptations. Nature 479(7374):487-492.
  • El-Mergawy R.A.A.M., Faure N., Avand-Faghih A., Rochat D., Nasr M. I., Silvain J.-F. Mitochondrial genetic variation and invasion history of the Red Palm Weevil Rhynchophorus ferrugineus Coleoptera: Curculionidae) in Middle-East and Mediterranean basin. Int. J. Agric. Biol. 13:631-637.
  • Félix A.-E., Calatayud P.-A., Le Rü B., Silvain J.-F., Frérot B. Sex pheromone composition and reproductive isolation in two Busseola species (Lepidoptera: Noctuidae) in Kenya. Chemoecology 21:107–111.
  • Gu Y., Rospars J.-P. Dynamical modeling of the moth pheromone-sensitive olfactory receptor. PLoS One 6(3):e17422.
  • Guittard E., Blais C., Maria A., Parvy J.-P., Pasricha P., Lumb C., Lafont R., Daborn P. J., Dauphin-Villemant C. CYP18A1, a key enzyme of Drosophila steroid hormone inactivation, is essential for metamorphosis. Dev. Biol. 349:35–45.
  • Inoshita T., Martin J.-R., Marion-Poll F., Ferveur J.-F. Peripheral, central and behavioral responses to the cuticular pheromone bouquet in Drosophila. PLoS One 6(5):e19770.
  • Kollmann M., Minoli S., Bonhomme J., Homberg U., Schachtner J., Tagu D., Anton S. Revisiting the anatomy of the central nervous system of a hemimetabolous model insect species: the pea aphid Acyrthosiphon pisum. Cell Tissue Res. 343:343–355.
  • Kumpun S., Girault J.-P., Dinan L., Blais C., Maria A., Dauphin-Villemant C., Yingyongnarongkul B., Suksamrarn A., Lafont R. The metabolism of 20-hydroxyecdysone in mice: relevance to pharmacological effects and gene switch applications of ecdysteroids. J. Steroid Biochem. Mol. Biol. 126:1-9.
  • Legeai F., Malpel S., Montagne N., Monsempes C., Cousserans F., Merlin C., François M.-C., Maibeche-Coisne M., Gavory F., Poulain J., Jacquin-Joly E. An Expressed Sequence Tag collection from the male antennae of the Noctuid moth Spodoptera littoralis: a resource for olfactory and pheromone detection research. BMC Genomics 12:86.
  • Login F.H., Balmand S., Vallier A., Vincent-Monégat C., Vigneron A., Weiss-Gayet M., Rochat D., Heddi A. Anti-microbial peptides keep insect endosymbionts under control. Science. 334:362-365.
  • Maniania N.K., Ouna E., Ahuya P., Frérot B., Félix A.E., Le Ru B., Calatayud P.-A. Dissemination of entomopathogenic fungi using Busseola fusca male as vector. Biol. Control. 58:374-378.
  • Moyal P., Tokro P., Bayram A.,Savopoulou-Soultani M., Conti E., Eizaguirre M., Le Rü B., Avand-Faghih A., Frérot B., Andreadis S. Origin and taxonomic status of the Palearctic population of the stem borer Sesamia nonagrioides (Lefèbvre) (Lepidoptera: Noctuidae). Biol. J. Linn. Soc. 103:904–922.
  • Olivier V., Monsempes C., François M.-C., Poivet E., Jacquin-Joly E. Candidate Chemosensory Ionotropic Receptors in a Lepidoptera. Insect Mol. Biol. 20(2):189-199.
  • Ozaki K., Ryuda M., Yamada A., Utoguchi A., Ishimoto H., Calas D., Marion-Poll F., Tanimura T., Yoshikawa H. A gustatory receptor involved in host plant recognition for oviposition of a swallowtail butterfly. Nature Comm. 2:542.
  • Rharrabe K., Sayah F., Marion-Poll F. Gustatory perception of phytoecdysteroids in Plodia interpunctella larvae. Entomol. Exp. App. 138(1):33-39.
  • Rouyar A., Party V., Prešern J., Blejec A., Renou M. A general odorant background affects the coding of pheromone stimulus intermittency in specialist olfactory receptor neurones. PLoS One 6(10): e26443.
  • Saïd I, Kaabi B., Rochat D. Evaluation and modeling of synergy to pheromone and plant kairomone in American palm weevil. Chem. Cent. J. 5:14.
  • Salloum A., Colson V., Marion-Poll M. Appetitive and aversive learning in Spodoptera littoralis larvae. Chem. Senses 36:725-731.
  • Sellier M.-J., Reeb P., Marion-Poll F. Consumption of bitter alkaloids in Drosophila melanogaster in multiple choice test conditions. Chem. Senses 36(4):323-334.
  • Soyez D., Toullec J.-Y., Montagné N., Ollivaux C. Experimental strategies for the analysis of D-amino acid containing peptides in crustaceans: a review. J. Chromato. 879:3102-3107.
  • Varela N., Avilla J., Gemeno C., Anton S. Ordinary glomeruli process sex pheromone and host plant volatiles in the antennal lobe of males and females in the tortricid moth Grapholita molesta (Busck) (Lepidoptera: Tortricidae). J. exp. Biol. 214:637-645.
  • Varela N., Avilla J., Anton S., Gemeno C. Synergism of pheromone and host-plant volatile blends in the attraction of Grapholita molesta males. Entomol. exp. appl. 141:114-122.
  • Zavada A., Buckley C., Martinez D., Rospars J.-P., Nowotny T. Competition-based model of pheromone component ratio detection in the moth. PLoS One 6(2):e16308.


  • Barrozo R.B., Jarriault D., Simeone X., Gaertner C., Gadenne C., Anton S. Mating-induced transient inhibition of responses to sex pheromone in a male moth is not mediated by octopamine or serotonin. J. exp. Biol. 213:1100-1106.
  • Barrozo R.B., Gadenne C., Anton S. Switching attraction to inhibition: mating-induced reversed role of sex pheromone in an insect. J. exp. Biol. 213:2933-2939.
  • Barrozo R.B., Gadenne C., Anton S. Post-mating sexual abstinence in a male moth. Comm. Integ. Biol. 3(6):629-630.
  • Blais C., Blasco T., Maria A., Dauphin-Villemant C., Lafont R. Characterization of ecdysteroids in Drosophila melanogaster by enzyme immunoassay and nano-liquid chromatography-tandem mass spectrometry. J. Chromatogr. B 878(13-14):925-932
  • Chabaud M.-A., Préat T., Kaiser L. Behavioral characterization of individual olfactory memory retrieval in Drosophila melanogaster. Front. Behav. Neurosci. 4:1-11.
  • Chertemps T., Mitri C., Perrot S., Sautereau J., Jacques J.-C., Thiery I., Bourgouin C., Rosinski-Chupin I. Anopheles gambiae PRS1 modulates plasmodium development at both midgut and salivary gland steps. PLoS ONE 5(7):e11538.
  • Chouquet B., Lucas P., Bozzolan F., Solvar M., Maïbèche-Coisné M., Durand N., Debernard S. Molecular characterization of a phospholipase C ß potentially involved in moth olfactory transduction. Chem. Senses 35:363-373.
  • Cottin D., Shillito B., Chertemps T., Tanguy A., Leger N., Ravaux J. Identification of differentially expressed genes in the hydrothermal vent shrimp Rimicaris exoculata exposed to heat stress. Marine Genomics 3:71-78.
  • Cottin D., Shillito B., Chertemps T., Thatje S., Leger N., Ravaux J. Comparison of heat-shock responses between the hydrothermal vent shrimp Rimicaris exoculata and the related coastal shrimp Palaemonetes varians. J. Exp. Marine Biol. Ecol. 393:9-16.
  • Deisig N., Giurfa M., Sandoz J.-C. Antennal lobe processing increases separability of odor mixture representations in the honeybee. J. Neurophysiol. 103-2185-2194.
  • Duportets L., Barrozo R.B., Bozzolan F., Gaertner C., Anton S., Gadenne C., Debernard S. Cloning of an octopamine/tyramine receptor and plasticity of its expression as a function of adult sexual maturation in the male moth, Agrotis ipsilon. Insect Molec. Biol. 19:489-499.
  • Durand N., Carot-Sans G., Chertemps T., Montagné N., Jacquin-Joly E., Debernard S., Maïbèche-Coisné M. A diversity of putative carboxylesterases are expressed in the antennae of the noctuid moth Spodoptera littoralis. Insect Molec. Biol. 19:87-97.
  • Durand N., Carot-Sans G., Chertemps T., Bozzolan F., Party V., Renou M., Debernard S., Rosell G., Maïbèche-Coisné M. Characterization of an antennal carboxylesterase from the pest moth Spodoptera littoralis degrading a host plant odorant. PLoS One 5(11):e15026.
  • Jarriault D., Gadenne C., Lucas P., Rospars J.-P., Anton S. Transformation of the sex pheromone signal in the noctuid moth Agrotis ipsilon: from peripheral input to antennal lobe output. Chem. Senses 35:705-715.
  • Lalouette L, Renault D, Ravaux J, Siaussat D Effects of cold-exposure and subsequent recovery on cellular proliferation with influence of 20-hydroxyecdysone in a lepidopteran cell line (IAL-PID2). Comp. Biochem. Physiol. 155:407-414.
  • Montagné N., Desdevises Y., Soyez D., Toullec J.-Y. Molecular evolution of the crustacean hyperglycemic hormone family in ecdysozoans. BMC Evol. Biol. 10:62-77.
  • Pézier A., Grauso M., Acquistapace A., Monsempes C., Rospars J.-P., Lucas P. Calcium activates a chloride conductance likely involved in olfactory receptor neuron repolarisation in the moth Spodoptera littoralis. J. Neurosci. 30:6323-6333.
  • Rospars J.-P. Terrestrial biological evolution and its implication for SETI. Acta Astronautica 67(11-12):1361-1365.
  • Rospars J.-P., Gu Y., Grémiaux A., Lucas P. Odour transduction in olfactory receptor neurons. Chinese J. Physiol. 53(6):364-372.
  • Wright G.A., Mustard J.A., Simcock N.K., Ross-Taylor A.A.R., McNicholas L.D., Popescu A., Marion-Poll F. Parallel reinforcement pathways for conditioned food aversions in the Honeybee. Curr. Biol. 20(24):2234-2240.


  • Anderson A.R., Wanner K.W., Trowell S.C., Warr C.G., Jacquin-Joly E., Zagatti P., Robertson H., Newcomb R.D. Functional analysis of female-biased odorant receptors from the silkworm, Bombyx mori. Insect Biochem. Molec. Biol. 39:189-197.
  • Barrozo R., Couton L., Lazzari C., Insausti T., Minoli S., Fresquet N., Rospars J.-P., Anton S. Antennal pathways in the central nervous system of a blood-sucking bug, Rhodnius prolixus. Arthropod Structure Dev. 38 :101-110.
  • Brigaud I., Grosmaître X., François M.-C., Jacquin-Joly E. Cloning and expression pattern of a putative octopamine/tyramine receptor in antennae of the noctuid moth Mamestra brassicae. Cell Tissue Res. 335:455–463.
  • Brigaud I., Montagné N., Monsempes C., François M.-C., Jacquin-Joly E. Identification of an atypical insect olfactory receptor subtype highly conserved within noctuids FEBS J. 276:6537-6547.
  • Calas D., Marion-Poll F., Steinbauer M.-J. Tarsal taste sensilla of the autumn gum moth, Mnesampela privata: morphology and electrophysiological activity. Entomol. exp. appl. 133:186-192.
  • Chouquet B., Debernard S., Bozzolan F., Solvar M., Maïbèche-Coisné M., Lucas P. A TRP channel is expressed in Spodoptera littoralis antennae and is potentially involved in insect olfactory transduction. Insect Molec. Biol. 18:213-222.
  • Couton L., Minoli S., Kiêu K., Anton S., Rospars J.-P. Constancy and variability of identified glomeruli in the antennal lobes: Computational approach in Spodoptera littoralis. Cell Tissue Res. 337:491-511.
  • Félix A.-E., Genestier G., Malosse C., Calatayud P.-A., Le Rü B., Silvain J.-F., Frérot B. Variability in pheromone communication among different haplotype populations of Busseola fusca. J Chem Ecol 35:618-623.
  • Gu Y., Lucas P., Rospars J.-P. Computational model of the insect pheromone transduction cascade. PLoS Comput. Biol. 5(3):e1000321.
  • Halnes G., Ulfhielm E., Eklöf Ljungren E., Hellgren Kotaleski J., Rospars J.-P. Modelling and sensitivity analysis of the reactions involving receptor, G-protein and effector in vertebrate olfactory receptor neurons. J. Comput. Neurosci. 27:471-491.
  • Hayase S., Renou M., Itoh T. Possible origin of modified EAG activity by point-fluorination of insect pheromones. Future Med. Chem. 1:838-845.
  • Jarriault D., Gadenne C., Rospars J.-P., Anton S. Quantitative analysis of sex-pheromone coding in the antennal lobe of the moth Agrotis ipsilon: a tool to study network plasticity. J. exp. Biol. 212:1191-1201.
  • Jarriault D., Barrozo R.B., de Carvalho Pinto C.J., Greiner B., Dufour M.C., Masante-Roca I., Gramsbergen J.B., Anton S., Gadenne C. Age-dependent plasticity of sex pheromone response in the moth, Agrotis ipsilon: combined effects of octopamine and juvenile hormone. Hormones Behav. 56:185-191.
  • Meunier N., Marion-Poll F., Lucas P. Water-taste transduction pathway is calcium-dependent in Drosophila. Chem. Senses 34:441-449.
  • Party V., Hanot C., Said I., Rochat D., Renou M. Plant Terpenes Affect Intensity and Temporal Parameters of Pheromone Detection in a Moth. Chem. Senses 34:763-774.
  • Piesik D., Rochat D., van der Pers J., Marion-Poll F. Pulsed odors from maize or spinach elicit orientation in European corn borer neonate larvae. J. chem. Ecol. 35:1032-1042.
  • Ravaux J, Cottin D, Chertemps T, Hamel G, Shillito B Hydrothermal vent shrimps display low expression of the heat-inducible hsp70 gene in nature. Mar. Ecol. Prog. Ser. 396:153-156
  • Sandström M., Lansner A., Hellgren-Kotaleski J., Rospars J.-P. Modeling the response of a population of olfactory receptor neurons to an odorant. J. Comput. Neurosci. 27:337-355.
  • Steinbauer M. J., Davies N. W., Gaertner C., Derridj S. Epicuticular waxes and plant primary metabolites on the surfaces of juvenile Eucalyptus globulus and E. nitens (Myrtaceae) leaves. Australian J. Botany 57:474-485.
  • Varela N., Couton L., Gemeno C., Avilla J., Rospars J.-P., Anton S. Three-dimensional antennal lobe atlas of the Oriental fruit moth, Cydia molesta (Busck) (Lepidoptera: Tortricidae): comparison of male and female glomerular organization. Cell Tissue Res. 337:513-526.


  • Alaphilippe A., Elad Y., Rav David D., Derridj S., Gessler C. Effects of a biocontrol agent of apple powdery mildew (Podosphaera leucotricha) on the host plant and on non-target organisms: an insect pest (Cydia pomonella) and a pathogen (Venturia inaequalis). Biocontrol Sci. Technol. 182:121-138.
  • Allou K., Morin J.-P., Kouassi P., Hala N’klo F., Rochat D. Sex ratio and female sexual status of the coconut pest, Oryctes monoceros (Coleoptera: Dynastidae), differ in feeding gallery and pheromone-baited trap. Bull. Entomol. Res. 98:581-586.
  • Bathellier C., Badeck F.-W., Couzi P., Harscoët S., Mauve C., Ghashghaie J. Divergence in d13C of dark respired CO2 and bulk organic matter occurs during the transition between heterotrophy and autotrophy in Phaseolus vulgaris plants. New Phytologist 177:406–418.
  • Calatayud P.-A., Ahuya P.O., Wanjoya A., Le Rü B., Silvain J.-F., Frérot B. Importance of plant physical cues in host acceptance for oviposition by Busseola fusca. Entomol. Exp. App. 126:233-243.
  • Charlier L., Antonczak S., Jacquin-Joly E., Cabrol-Bass D., Golebiowski J. Deciphering the selectivity of Bombyx mori Pheromone Binding Protein for Bombykol over Bombykal. A theoretical approach. Chem. Phys. Chem. 9:2785-2793.
  • Chouquet B., Bozzolan F., Solvar M., Duportets L., Jacquin-Joly E., Lucas P., Debernard S. Molecular cloning and expression patterns of a putative olfactory DGK from the noctuid moth Spodoptera littoralis. Insect Molec. Biol. 17:485-493.
  • Hiroi M., Tanimura T., Marion-Poll F. Hedonic taste in Drosophila revealed by olfactory receptors expressed in taste neurons. PLoS One 3(7):e2610.
  • Kostal L., Lansky P., Rospars J.-P. Efficient olfactory coding in the pheromone receptor neuron of a moth. PLoS Comput. Biol. 4(4): e1000053.
  • Lansky P., Pokora A., Rospars J.-P. Classification of stimuli based on stimulus-response curves and their variability. Brain Res. 1225:57-66.
  • Lombarkia N., Derridj S. Resistance of apple trees to Cydia pomonella egg-laying due to leaf surface metabolites. Entomol. Exp. App. 128:57-65.
  • Malpel S., Merlin C., François M.-C., Jacquin-Joly E. Molecular identification and characterization of two new Lepidoptera chemoreceptors belonging to the Drosophila melanogaster OR83b family. Insect Molec. Biol. 17:587-596.
  • Rospars J.-P., Lansky P., Chaput M., Duchamp-Viret P. Competitive and noncompetitive odorant interactions in the early neural coding of odorant mixtures. J. Neurosci. 28:2659-2666.
  • Siaussat D., Bozzolan F., Porcheron P., Debernard S. The 20-hydroxyecdysone-induced signalling pathway in G2/M arrest of Plodia interpunctella imaginal wing cells. Insect Molec. Biol. 38(5):529-539.
  • Vidybida A.K., Usenko A.S., Rospars J.-P. Selectivity improvement in a model of olfactory receptor neuron with adsorption-desorption noise. J. Biol. Systems 16:531-545.


  • Anderson P., Hansson B.S., Nilsson U., Han Q., Sjöholm M., Skals, N. & Anton S. Increased behavioral and neuronal sensitivity to sex pheromone after brief odor experience in a moth. Chem. Senses 32:483-491.
  • Anton S., Dufour M.C. & Gadenne C. Plasticity of olfactory-guided behaviour and its neurobiological basis: lessons from moths and locusts. Ent. exp. appl. 123:1-11.
  • Calas D., Berthier A., Marion-Poll F. Do females of the European corn borer, Ostrinia nubilalis, detect and avoid laying eggs on 20-hydroxyecdysone? J. Chem. Ecol. 33:1393-1404.
  • Ghaioule D., Lumaret J.-P., Rochat D., Maatouf N. & Niogret J. Evaluations des dégâts par les vers blancs (Coleoptera : Scarabaeoidea) dans les parcelles de régénération du chêne-liège (Quercus suber L.) en forêt de la Mamora (Maroc) et recherche des médiateurs chimiques pour une lutte biologique. Ann. Soc. Entomol. Fr. 43:1-8
  • Jørgensen K., Jørgen-Almaas T., Marion-Poll F. & Mustaparta H. Electrophysiological characterization of responses from gustatory receptor neurons of sensilla chaetica in the moth Heliothis virescens. Chem. Senses 32:863-879.
  • Kostal L., Lansky P. & Rospars J.-P. Encoding of pheromone intensity by dynamic activation of pheromone receptors. Neurocomputing 70:1759-1763.
  • Kostal L., Lansky P. & Rospars J.-P. Neuronal coding and spiking randomness. Eur. J. Neuroscience 26:2693-2701.
  • Lacaille F., Hiroi M., Twele R., Inoshita T., Umemoto D., Maniere G., Marion-Poll F., Ozaki M., Francke W., Cobb M., Everaerts C., Tanimura T. & Ferveur J.-F. An inhibitory sex pheromone tastes bitter for Drosophila males. PLoS ONE 2:e661.
  • Masante-Roca I., Anton S., Delbac L., Dufour M.C. & Gadenne C. Attraction of the grapevine moth to host and non-host plant parts in the wind tunnel: effects of plant phenology, sex, and mating status. Ent. exp. appl. 122:239-245.
  • Merlin C., Rosell G., Carot-Sans G., François M.-C., Bozzolan F., Jacquin-Joly E., Guerrero A. & Maïbèche-Coisné M. Antennal Esterase cDNAs from two pest moths, Spodoptera littoralis and Sesamia nonagrioides, potentially involved in odorant degradation. Insect Molec. Biol. 16:73-81.
  • Merlin C., Lucas P., Rochat D., François M.-C., Martine Maïbèche-Coisne & Jacquin-Joly E. Antennal circadian clock and circadian rhythms in the peripheral pheromone reception in the moth Spodoptera littoralis J. Biol. Rhythms 22:502-514.
  • Nemer N., Kfoury L., Kawar N., and Frérot B. Evidence of a sexual attraction by pheromone in the cedar web-spinning sawfly. Can. Entomol. 139:713–721.
  • Pelletier J., Bozzolan F., Solvar M., François M.-C., Jacquin-Joly E. & Maïbèche-Coisné M. Identification of candidate aldehyde oxidases from the silkworm Bombyx mori potentially involved in antennal pheromone degradation. Gene 404:31-40.
  • Pézier A., Acquistapace A., Renou M., Rospars J.-P. & Lucas P. Ca2+ stabilizes the membrane potential of moth olfactory receptor neurons at rest and is essential for their fast repolarization. Chem. Senses 32:305-317.
  • Rospars J.-P., Lucas P. & Coppey M. Modelling the early steps of transduction in insect olfactory receptor neurons. Biosystems 89:101-109.
  • Sauphanor B., Franck P., Lasnier T., Toubon J.-F, Beslay D., Boivin T., Bouvier J.-C. & Renou M. Insecticide resistance may enhance the response to a host-plant volatile kairomone for the codling moth, Cydia pomonella (L.). Naturwissenschaften 94:449-458.
  • Siaussat, D., Bozzolan, F., Porcheron, P. & Debernard, S. Identification of steroid hormone signaling pathway in insect cell differentiation. Cell. Molec. Life Sci. 64:365-376.


  • Allou K., Morin J.-P., Kouassi P., Hala N'klo, F. & Rochat D. Oryctes monoceros trapping with pheromone and palm material in Ivory Coast. J. chem. Ecol. 32:1743-1754.
  • Calas, D., Thiery, D. & Marion-Poll, F. 20-Hydroxyecdysone deters oviposition and larval feeding in the European grapevine moth, Lobesia botrana. J. chem. Ecol. 32:2443-2454.
  • Calatayud P.-A., Chimtawi M., Tauban D., Marion-Poll F., Le Rü B., Silvain J.-F., Frérot B. Sexual dimorphism of antennal, tarsal and ovipositor chemosensilla in the African stemborer, Busseola fusca (Fuller) (Lepidoptera: Noctuidae). Ann. Soc. Entomol. Fr. 42:403-412.
  • de Santis F., François M.-C., Merlin C., Pelletier J., Maïbèche-Coisné M., Conti E. & Jacquin-Joly E. Molecular cloning and in situ expression patterns of Two New Pheromone-Binding Proteins from the Corn Stemborer Sesamia nonagrioides. J. chem. Ecol. 32:1703-1717.
  • Dufour M.C. & Gadenne C. Adult neurogenesis in a moth brain. J. comp. Neurol. 495:635-643.
  • Frérot B., Felix A.-E., Sarapuu E., Calatayud P.A., Le Ru B. & Guénégo H. Courtship behaviour of the African maize stem borer: Busseola fusca (Fuller) (Lepidoptera : Noctuidae) under laboratory conditions. Ann. Soc. Entomol. France 42:413-416
  • Malausa T., Salles M., Marquet V., Guillemaud T., Alla S., Marion-Poll F. & Lapchin L. Within-species variability of the response to 20-hydroxyecdysone in peach–potato aphid (Myzus persicae Sulzer). J. insect Physiol. 52:480-486.
  • Saïd I. & Rochat D. Adaptation of a four-arm olfactometer for behavioural bioassays of large insects. Chemoecology 16:9-16.
  • Sureda T., Quero C., Bosch M.-P., Aviles R., Coll F., Renou M. & Guerrero A. Electrophysiological and behavioral responses of a cuban population of the sweet potato weevil to its sex pheromone. J. chem. Ecol. 32:2177-2190.


  • Auzoux-Bordenave S., Solvar M., Queguiner I., Bozzolan F., Mottier V., Siaussat D., Porcheron P., Debernard S. Comparative effects of a non-steroidal ecdysone agonist RH-5992 and 20-hydroxyecdysone in a lepidopteran cell line (IAL-PID2). Insect Biochem. Mol. Biol. 35(9):1033-1042.
  • Bethenod, M.-T., Thomas Y., Rousset F., Frérot B., Pelozuelo L., Genestier G. & Bourguet D. Genetic isolation between two sympatric host plant races of the European corn borer, Ostrinia nubilalis Hübner. II: Assortative mating and host-plant preferences for oviposition. Heredity, 94:264-270.
  • Duchamp-Viret P., Kostal L., Chaput M., Lansky P., Rospars J-P. Patterns of spontaneous activity in single rat olfactory receptor neurons are different in normally breathing and tracheotomized animals. J. Neurobiol., 65:97-114.
  • Han Q., Hansson B.S. & Anton S. Interactions of mechanical stimuli and sex pheromone information in antennal lobe neurons of a male moth, Spodoptera littoralis. J. comp. Physiol., 191:521-528.
  • Hayase S., Renou M. & Itoh T. Possible origin of modified EAG activity by point-fluorination of the insect pheromone eldanolide. Eur. J. org. Chem., 2005:2777-2781.
  • Jacquin-Joly E. & Lucas P. Pheromone reception and transduction: mammals and insects illustrate converging mechanisms across phyla. Current Topics Neurochem., 4:75-105.
  • Maïbèche-Coisné M., Merlin C., François M.-C., Porcheron P. and Jacquin-Joly E. Cytochrome P450 and P450 reductase cDNAs from the moth Mamestra brassicae: cloning and expression patterns in male antennae. Gene, 346:195-203.
  • Masante-Roca I., Gadenne C. & Anton S. Three-dimensional antennal lobe atlas of male and female moths, Lobesia botrana (Lepidoptera: Tortricidae) and glomerular representation of plant volatiles in females. J. exp. Biol., 208:1147-1159.
  • Mensah R., Frérot B. & Al Dabel F. Effects of petroleum spray oils on oviposition behaviour and larval survival of Helicoverpa armigera Hübner (Lepidoptera: Noctuidae) and Ostrinia nubilalis Hübner (Lepidoptera: Pyralidae). Int. J. Pest Management, 51:111-119.
  • Merlin C., François M.-C., Bozzolan F., Pelletier J., Jacquin-Joly E. and Maïbèche-Coisné M. A new aldehyde oxidase selectively expressed in chemosensory organs of insects. Biochem. Biophys. Res. Comm., 332:4-10.
  • Miller N., Estoup A., Toepfer S., Bourguet D., Lapchin L., Derridj S., Kim K.S., Reynaud P., Furlan L., Guillemaud T. Multiple Transatlantic Introductions of the Western Corn Rootworm. Science, 310:992.
  • Saïd I. , Renou M., Morin J.-P., Ferreira J.M.S. & Rochat D. Interactions between acetoin, a plant volatile and pheromone in Rhynchophorus palmarum: behavioral and olfactory neuron responses. J. chem. Ecol., 31:1789-1805.
  • Siaussat, D. , Bozzolan, F., Queguinner, I. , Porcheron, P., Debernard, S. Cell cycle profiles of EcR, USP, HR3 and B cyclin mRNAs associated to 20E-induced G2 arrest of Plodia interpunctella imaginal wing cells. Insect Mol. Biol., 14:151-161.
  • Toth J. & Rospars J.-P. Dynamic modeling of biochemical reactions with application to signal transduction: principles and tools using Mathematica. Biosystems, 79:33-52.
  • Zufall F., Ukhanov K., Lucas P., Leinders-Zufall T. Neurobiology of TRPC2: from gene to behaviour. Pflügers Arch. - Eur. J. Physiol., 451:61-71.
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