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Phosphorylation of proteins and human diseases - USR 3051

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Phosphorylation of Proteins and Human Diseases

Protein phosphorylation is one of the post-translational mechanisms developed by cells to finely regulate metabolic pathways. Protein kinases involved in phosphorylation are responsible for many human diseases. This is the reason why research into the phosphorylation of proteins and the development of screening methods to identify selective inhibitors of protein kinases has increased dramatically in recent years. Based on the work done on the early stages of cell division in sea urchin embryos and starfish oocytes, the lab's research has focused on several families of protein kinases potentially relevant to the treatment of certain human diseases.

 

The basic research details the role of several protein kinases involved in cell proliferation mechanisms and neuronal functions and the mode of action and selectivity of inhibitors of these kinases. This work enabled the identification, optimization and characterization of several families of protein-kinase inhibitors: olomoucine, roscovitine, purvalanol, paullures, indirubnes, hymenialdisine, meridianines, meriolines.

 

Some of these compounds are in the pre-clinical testing phase for neurodegenerative diseases, renal diseases or malaria. Others are in clinical trial phase for their anti-tumor properties such as roscovitine, currently tested to treat lung cancer, nasopharyngeal cancer, and breast cancer.

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Director
RUCHAUD Sandrine
+33 (0)2 98 29 23 09
sandrine.ruchaud@sb-roscoff.fr
Physical address
Station Biologique de Roscoff
Place Georges Teissier
29680 Roscoff, France

Laboratory e-mail
Web site
http://www.sb-roscoff.fr/fr/phosphorylation-de-proteines-et-pathologies-humaines
Postal address


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Administrative contact
 





12/04/16