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Claire de Thoisy-Méchin

Press Relations

Tel. +33 (0)1 44 27 23 34

Email: claire.de_thoisy-mechin@upmc.fr


In English:

Katherine Tyrka

International Press Relations

tel. +33 (0)1 44 27 51 05

Email: katherine.tyrka@upmc.fr

Obesity and T2 Diabetes:are there cells at the junction of the microbiota and inflammation?

Scientists at Institut Cochin (CNRS/Inserm/Université Paris Descartes) and ICAN – Institute of Cardiometabolism And Nutrition (Inserm/UPMC/AP-HP) have discovered that a class of inflammatory cells, MAIT lymphocytes, is deregulated in patients suffering from type 2 diabetes and obesity. In these patients, bariatric surgery (or a gastric bypass), which relieves inflammation, can restore the normal functioning of MAIT cells. Already known to be activated by certain bacterial populations and to favor inflammation, these cells may explain the link between alterations that affect the intestinal flora (microbiota) and the inflammatory nature of these diseases. These findings are published on 9 March 2015 in Journal of Clinical Investigation.

Type 2 diabetes and obesity are severe and intimately related pathological conditions whose incidence is increasing in France4 and throughout the world. These diseases with multiple causes (dietary changes, sedentary lifestyle, combined with genetic predispositions) are associated with chronic inflammation, induced by the immune system, which is abnormally activated. This inflammation is present not only in the blood but also in the organs involved in metabolic control of the body, such as the liver and adipose tissue. It also contributes to a loss of glycemic control. Furthermore, recent studies have shown that the gut flora of diabetic and obese patients is modified to a significant degree.

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