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Claire de Thoisy-Méchin

Press Relations

Tel. +33 (0)1 44 27 23 34

Email: claire.de_thoisy-mechin@upmc.fr

 

In English:

Katherine Tyrka

International Press Relations

tel. +33 (0)1 44 27 51 05

Email: katherine.tyrka@upmc.fr

Combining magnetism and light to fight cancer

Researchers at the Laboratoire Physicochimie des Electrolytes et Nanosystèmes Interfaciaux (CNRS/UPMC) and the Laboratoire Matière et Systèmes Complexes (CNRS/Université Paris Diderot) achieved complete tumor regression in mice. Their method: combining magnetic nanoparticles and photosensitizers in a particularly innovative liposome1 and then activate them simultaneously and remotely with external physical stimuli (a magnetic field and light).

By directly injecting the liposome into the tumor, it becomes possible to increase the temperature (magnetic hyperthermia) and release, by light, chemical reactive oxygen species highly toxic to the latter (PDT). In mice, these two techniques have allowed researchers to fully destroy cancerous cells. Non-toxic unless activated, this type of therapy also has fewer side effects. Researchers will now exploit other magnetic properties of liposomes to deliver effectively to tumors after injection into the bloodstream.

1 an artificial bladder with an internal compartment formed by lipid bilayers

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Photo credit : wikimedia commons - rights reserved. Cancerous breast cell.



03/04/15